Reduced Transient Outward K + Current and Cardiac Hypertrophy
نویسندگان
چکیده
منابع مشابه
Reduced transient outward K+ current and cardiac hypertrophy: causal relationship or epiphenomenon?
Action potentials coordinate contraction and relaxation of the heart. The long plateau phase of the action potential ensures sufficient Ca entry into the cytoplasm via L-type Ca channels to invoke Ca -induced Ca release from the sarcoplasmic reticulum and activation of the contractile filaments. Action potentials are initiated by opening of voltage-gated Na channels that in turn rapidly depolar...
متن کاملTransient Outward Current?
To gain insight into the molecular basis of cardiac repolarization, we have expressed K' channels cloned from ventricular myocardium in Xenopus oocytes. A recently identified human cardiac K' channel isoform (human Kvl.4) has properties similar to the 4-aminopyridine-sensitive calcium-insensitive component of the cardiac transient outward current. However, these channels recovered from inactiva...
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A novel transient outward K(+) current that exhibits inward-going rectification (I(to.ir)) was identified in guinea pig atrial and ventricular myocytes. I(to.ir) was insensitive to 4-aminopyridine (4-AP) but was blocked by 200 micromol/l Ba(2+) or removal of external K(+). The zero current potential shifted 51-53 mV/decade change in external K(+). I(to.ir) density was twofold greater in ventric...
متن کاملTransient outward current, Ito1, is altered in cardiac memory.
BACKGROUND Cardiac memory refers to an altered T-wave morphology induced by ventricular pacing or arrhythmias that persist for variable intervals after resumption of sinus rhythm. METHODS AND RESULTS We induced long-term cardiac memory (LTM) in conscious dogs by pacing the ventricles at 120 bpm for 3 weeks. ECGs were recorded daily for 1 hour, during which time pacing was discontinued. At ter...
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Shi, Hong, Hui-Zhen Wang, and Zhiguo Wang. Extracellular Ba21 blocks the cardiac transient outward K1 current. Am. J. Physiol. Heart Circ. Physiol. 278: H295–H299, 2000.—Ba21 is widely used as a tool in patch-clamp studies because of its ability to block a variety of K1 channels and to pass Ca21 channels. Its potential ability to block the cardiac transient outward K1 current (Ito) has not been...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2002
ISSN: 0009-7330,1524-4571
DOI: 10.1161/01.res.0000014284.39141.8c